Article
Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
PloS one - 1 Jan 2017
Morimoto Takaaki, Mineharu Yohei, Ono Koh, Nakatochi Masahiro, Ichihara Sahoko, Kabata Risako, Takagi Yasushi, Cao Yang, Zhao Lanying, Kobayashi Hatasu, Harada Kouji H, Takenaka Katsunobu, Funaki Takeshi, Yokota Mitsuhiro, Matsubara Tatsuaki, Yamamoto Ken, Izawa Hideo, Kimura Takeshi, Miyamoto Susumu, Koizumi Akio
Abstract excerpt
BACKGROUND: The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a risk factor for coronary artery...
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