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Variant allele frequency: a decision-making tool in precision oncology?

Trends in cancer - 1 Dec 2023

Boscolo Bielo Luca, Trapani Dario, Repetto Matteo, Crimini Edoardo, Valenza Carmine, Belli Carmen, Criscitiello Carmen, Marra Antonio, Subbiah Vivek, Curigliano Giuseppe

Abstract excerpt

Precision oncology requires additional predictive biomarkers for targeted therapy selection. Variant allele frequency (VAF), measuring the proportion of variant alleles within a genomic locus, provides insights into tumor clonality in somatic genomic testing, yielding a strong rationale for targeting dominant cancer cell populations. The prognostic and predictive roles of VAF have been evaluated across different...

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PMID: 37704501
DOI: 10.1016/j.trecan.2023.08.011

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