Article
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Cellular and molecular life sciences : CMLS - 28 Mar 2024
Xu Yuchen, Song Rui, Perszyk Riley E, Chen Wenjuan, Kim Sukhan, Park Kristen L, Allen James P, Nocilla Kelsey A, Zhang Jing, XiangWei Wenshu, Tankovic Anel, McDaniels Ellington D, Sheikh Rehan, Mizu Ruth K, Karamchandani Manish M, Hu Chun, Kusumoto Hirofumi, Pecha Joseph, Cappuccio Gerarda, Gaitanis John, Sullivan Jennifer, Shashi Vandana, Petrovski Slave, Jauss Robin-Tobias, Lee Hyun Kyung, Bozarth Xiuhua, Lynch David R, Helbig Ingo, Pierson Tyler Mark, Boerkoel Cornelius F, Myers Scott J, Lemke Johannes R, Benke Timothy A, Yuan Hongjie, Traynelis Stephen F
Abstract excerpt
N-methyl-D-aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission throughout the central nervous system. Genetic variants in GRIN genes encoding NMDAR subunits are associated with a spectrum of neurological disorders. The M3 transmembrane helices of the NMDAR couple directly to the agonist-binding domains and form a helical bundle crossing...
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