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Article

Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia.

BMC psychiatry - 29 Aug 2023

Xu Xusan, Luo Shucun, Wang Xiaoxia, Wen Xia, Yin Jingwen, Luo Xudong, He Bin, Liang Chunmei, Xiong Susu, Zhu Dongjian, Lv Dong, Dai Zhun, Lin Juda, Li You, Lin Zhixiong, Chen Wubiao, Luo Zebin, Wang Yajun, Ma Guoda

Abstract excerpt

Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. The cerebellum exhibits abundant expression of SAP97, which is involved with negative symptoms, cognition and emotion in schizophrenia. As functional dysconnectivity with the cortical-subcortical-cerebellar circuitry has been widely shown in...

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PMID: 37644438
DOI: 10.1186/s12888-023-05036-9
PMCID: PMC10464201

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