Article
Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 2023
Bhati Tanu, Ray Ankita, Arora Renu, Siraj Fouzia, Parvez Suhel, Rastogi Sangita
Abstract excerpt
PROBLEM: Spontaneous preterm birth (sPTB) is a global health issue. Studies suggest infection and infection-based inflammatory responses are major risk factors for sPTB. Considering the important role of anti-inflammatory proteins in pregnancy, the study aimed to find the association between anti-inflammatory LGALS13 gene variants IVS2-22 A/G (rs2233706) and IVS3+72 T/A (rs2233708) and the risk of sPTB during...
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