Article
Frequency of Atypical Mutations in the Spike Glycoprotein in SARS-CoV-2 Circulating from July 2020 to July 2022 in Central Italy: A Refined Analysis by Next Generation Sequencing.
Viruses - 9 Aug 2023
Bellocchi Maria Concetta, Scutari Rossana, Carioti Luca, Iannetta Marco, Marchegiani Greta, Piermatteo Lorenzo, Coppola Luigi, Tedde Simona, Duca Leonardo, Malagnino Vincenzo, Ansaldo Lorenzo, Braccialarghe Neva, D Anna Stefano, Santoro Maria Mercedes, Di Lorenzo Andrea, Salpini Romina, Teti Elisabetta, Svicher Valentina, Andreoni Massimo, Sarmati Loredana, Ceccherini-Silberstein Francesca, On Behalf Of The Ptv-Utv-Id-Covid Group
Abstract excerpt
In this study, we provided a retrospective overview in order to better define SARS-CoV-2 variants circulating in Italy during the first two years of the pandemic, by characterizing the spike mutational profiles and their association with viral load (expressed as ct values), N-glycosylation pattern, hospitalization and vaccination. Next-generation sequencing (NGS) data were obtained from 607 individuals (among...
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