Article
SGCD Missense Variant in a Lagotto Romagnolo Dog with Autosomal Recessively Inherited Limb-Girdle Muscular Dystrophy.
Genes - 18 Aug 2023
Brunetti Barbara, Bacci Barbara, Abbate Jessica Maria, Tura Giorgia, Paciello Orlando, Vaccaro Emanuela, Prisco Francesco, Gandini Gualtiero, Okonji Samuel, Paola Andrea di, Letko Anna, Drögemüller Cord, Jagannathan Vidhya, Turba Maria Elena, Ogundipe Tolulope Grace, Lorenzini Luca, Rosati Marco, Psalla Dimitra, Leeb Tosso, Drögemüller Michaela
Abstract excerpt
An 8-month-old female Lagotto Romagnolo dog was presented for a 1-month history of an initial severe reluctance to move, rapidly progressing to a marked stiff gait and progressive muscular weakness and evolving to tetraparesis, which persuaded the owner to request euthanasia. A primary muscle pathology was supported by necropsy and histopathological findings. Macroscopically, the muscles were moderately atrophic,...
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