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Article

Pan-cancer analysis identifies SPEN mutation as a predictive biomarker with the efficacy of immunotherapy.

BMC cancer - 24 Aug 2023

Li Ya-Dong, Huang Hao, Ren Zheng-Ju, Yuan Ye, Wu Hao, Liu Chuan

Abstract excerpt

The association between specific genetic mutations and immunotherapy benefits has been widely known, while such studies in pan-cancer are still limited. SPEN, mainly involved in X chromosome inactivation (XCI), plays an essential in tumorigenesis and sex differences in cancer. Thus, we firstly analyzed the potential role of SPEN in the TCGA pan-cancer cohort and clinical samples. Bioinformatics analysis and...

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Identifiers

PMID: 37620924
DOI: 10.1186/s12885-023-11235-0
PMCID: PMC10463702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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