Article
Knockdown resistance mutations are common and widely distributed in Xenopsylla cheopis fleas that transmit plague in Madagascar.
PLoS neglected tropical diseases - 1 Aug 2023
Hutton Shelby M, Miarinjara Adelaide, Stone Nathan E, Raharimalala Fara N, Raveloson Annick O, Rakotobe Harimanana Ravo, Harimalala Mireille, Rahelinirina Soanandrasana, McDonough Ryelan F, Ames Abbe D, Hepp Crystal, Rajerison Minoarisoa, Busch Joseph D, Wagner David M, Girod Romain
Abstract excerpt
BACKGROUND: Plague, caused by the bacterium Yersinia pestis, remains an important disease in Madagascar, where the oriental rat flea, Xenopsylla cheopis, is a primary vector. To control fleas, synthetic pyrethroids (SPs) have been used for >20 years, resulting in resistance in many X. cheopis populations. The most common mechanisms of SP resistance are target site mutations in the voltage-gated sodium channel...
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