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SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans

17 Aug 2023

Abstract excerpt

Secreted modular calcium-binding proteins (SMOCs) are conserved matricellular proteins found in organisms from Caenorhabditis elegans to humans. SMOC homologs characteristically contain 1 or 2 extracellular calcium-binding (EC) domain(s) and 1 or 2 thyroglobulin type-1 (TY) domain(s). SMOC proteins in Drosophila and Xenopus have been found to interact with cell surface heparan sulfate proteoglycans (HSPGs) to...

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PMID: 37590248
DOI: 10.1371/journal.pbio.3002272

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