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Article

Hematoxylin and Eosin Staining Helps Reduce Maternal Contamination in Short Tandem Repeat Genotyping for Hydatidiform Mole Diagnosis.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 May 2024

Zhao Yating, Cai Luya, Zhang Xiaofei, Zhang Huifang, Cai Limeng, Zhou Lin, Huang Bo, Qian Jianhua

Abstract excerpt

Short tandem repeat (STR) genotyping provides parental origin information about aneuploidy pregnancy loss and has become the current gold standard for hydatidiform mole diagnosis. STR genotyping diagnostic support most commonly relies on formalin-fixed paraffin-embedded samples, but maternal contamination is one of the most common issues based on traditional unstained sections. To evaluate the influence of...

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PMID: 37566880
DOI: 10.1097/PGP.0000000000000973
PMCID: PMC11022989

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