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Article

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R).

Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2023

Abo Al-Hamd Mahmoud G, Tawfik Haytham O, Abdullah Omeima, Yamaguchi Koki, Sugiura Masaharu, Mehany Ahmed B M, El-Hamamsy Mervat H, El-Moselhy Tarek F

Abstract excerpt

Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer cell lines, with GI % mean up to 74% for 10c. Expending erlotinib as a reference drug, target compounds were...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

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Identifiers

PMID: 37548154
DOI: 10.1080/14756366.2023.2241674
PMCID: PMC10408569

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