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Article

Discovery of EGF Receptor Inhibitors That Are Selective for the d746-750/T790M/C797S Mutant through Structure-Based de Novo Design.

Angewandte Chemie (International ed. in English) - 19 Jun 2017

Park Hwangseo, Jung Hoi-Yun, Mah Shinmee, Hong Sungwoo

Abstract excerpt

Next-generation epidermal growth factor receptor (EGFR) inhibitors against the d746-750/T790M/C797S mutation were discovered through two-track virtual screening and de novo design. A number of nanomolar inhibitors were identified using 2-aryl-4-aminoquinazoline as the molecular core and the modified binding energy function involving a proper dehydration term, which provides important structural insight into the...

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Identifiers

PMID: 28493467
DOI: 10.1002/anie.201703389

Genes

EGFR
EGF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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