Article
Receptor binding motif surrounding sites in the spike 1 protein of infectious bronchitis virus have high susceptibility to mutation related to selective pressure.
Journal of veterinary science - 1 Jul 2023
Hong Seung-Min, Kim Seung-Ji, An Se-Hee, Kim Jiye, Ha Eun-Jin, Kim Howon, Kwon Hyuk-Joon, Choi Kang-Seuk
Abstract excerpt
BACKGROUND: To date, various genotypes of infectious bronchitis virus (IBV) have co-circulated and in Korea, GI-15 and GI-19 lineages were prevailing. The spike protein, particularly S1 subunit, is responsible for receptor binding, contains hypervariable regions and is also responsible for the emerging of novel variants. OBJECTIVE: This study aims to investigate the putative major amino acid substitutions for the...
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