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Tumor microenvironment phenotypes and prognostic evaluation tools for osteosarcoma characterized by different prognostic outcomes and immunotherapy responses.

The journal of gene medicine - 1 Jan 2024

Tu Zubo, Li Wang, Chen Zhigang, Jiang Dong, Zhou Shiran, Lv Shujun, Cui Haidong

Abstract excerpt

BACKGROUND: The physiological and immunological characteristics of the tumor microenvironment (TME) have a profound impact on the effectiveness of immunotherapy. The present study aimed to define the TME subtype of osteosarcoma according to the signatures representing the global TME of the tumor, as well as create a new prognostic assessment tool to monitor the prognosis, TME activity and immunotherapy response...

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Bone Neoplasms
Immunotherapy
Osteosarcoma
Phenotype
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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PMID: 37525871
DOI: 10.1002/jgm.3572

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