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Role of haptoglobin 2-2 genotype on disease progression and mortality among South Indian chronic kidney disease patients.

Molecular biology reports - 1 Sept 2023

Vasudevan Varadaraj, Ramprasath Tharmarajan, Sampathkumar Krishnaswamy, Syed Mohamed Puhari Shanavas, Yuvaraj Subramani, Selvam Govindan Sadasivam

Abstract excerpt

BACKGROUND: Haptoglobin (HP), a plasma glycoprotein, binds to free hemoglobin and prevents the loss of iron and kidney damage. The variations of HP gene affect its enzyme activity, resulting in varied antioxidant, angiogenic and anti-inflammatory properties. HP 2-2 genotype showed 3.84 fold increased risk for the development of CKD in Taiwan population. With this background, the present work focused to conduct a...

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PMID: 37522948
DOI: 10.1007/s11033-023-08676-y

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