Article
Intracellular environment can change protein conformational dynamics in cells through weak interactions.
Science advances - 21 Jul 2023
Wang Mengting, Song Xiangfei, Chen Jingfei, Chen Xiaoxu, Zhang Xueying, Yang Ying, Liu Zhijun, Yao Lishan
Abstract excerpt
Conformational dynamics is important for protein functions, many of which are performed in cells. How the intracellular environment may affect protein conformational dynamics is largely unknown. Here, loop conformational dynamics is studied for a model protein in Escherichia coli cells by using nuclear magnetic resonance (NMR) spectroscopy. The weak interactions between the protein and surrounding macromolecules...
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