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Article

Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity.

Genome medicine - 21 Jul 2023

Shuaib Muhammad, Adroub Sabir, Mourier Tobias, Mfarrej Sara, Zhang Huoming, Esau Luke, Alsomali Afrah, Alofi Fadwa S, Ahmad Adeel Nazir, Shamsan Abbas, Khogeer Asim, Hashem Anwar M, Almontashiri Naif A M, Hala Sharif, Pain Arnab

Abstract excerpt

BACKGROUND: The excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of COVID-19. Previous work found that two adjacent co-occurring mutations R203K and G204R (KR) on the nucleocapsid (N) protein correlate with increased disease severity in COVID-19 patients. However, links with the host immune response remain unclear. METHODS: Here, we...

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Identifiers

PMID: 37475040
DOI: 10.1186/s13073-023-01208-0
PMCID: PMC10360309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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