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Relationship between circulating mitochondrial DNA and microRNA in patients with major depression

17 Jul 2023

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) and circulating cell-free mitochondrial DNA (ccf-mtDNA) have attracted interest as biological markers of affective disorders. In response to stress, it is known that miRNAs in mitochondria diffuse out of the cytoplasm alongside mtDNA; however, this process has not yet been identified. We hypothesized that miRNAs derived from specific cell nuclei cause mitochondrial damage and mtDNA...

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PMID: 37467797
DOI: 10.1016/j.jad.2023.07.073

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