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Article

Novel economical, accurate, sensitive, single-cell analytical method for mitochondrial DNA quantification in mtDNA mutation carriers.

Journal of assisted reproduction and genetics - 1 Sept 2023

Zou Weiwei, Zong Kai, Zhang Zhikang, Shen Lingchao, Wang Xiaolei, Su Xun, Wang Xin, Yin Tao, Liang Chunmei, Liu Yajing, Liang Dan, Hu Chao, Cao Yunxia, Ji Dongmei

Abstract excerpt

PURPOSE: Although a variety of analytical methods have been developed to detect mitochondrial DNA (mtDNA) heteroplasmy, there are special requirements of mtDNA heteroplasmy quantification for women carrying mtDNA mutations receiving the preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PD) in clinic. These special requirements include various sample types, large sample number, long-term follow-up,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37462790
DOI: 10.1007/s10815-023-02878-w
PMCID: PMC10440311

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