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Article

Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation.

Cells - 22 Jun 2023

Zhu Li, Brown Mark A, Sims Robert J, Tiwari Gayatri R, Nie Hui, Mayfield R Dayne, Tucker Haley O

Abstract excerpt

The SMYD family is a unique class of lysine methyltransferases (KMTases) whose catalytic SET domain is split by a MYND domain. Among these, Smyd1 was identified as a heart- and skeletal muscle-specific KMTase and is essential for cardiogenesis and skeletal muscle development. SMYD1 has been characterized as a histone methyltransferase (HMTase). Here we demonstrated that SMYD1 methylates is the Skeletal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37443729
DOI: 10.3390/cells12131695
PMCID: PMC10340688

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