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In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

26 Jun 2023

Abstract excerpt

The extracellular microenvironment regulates cell decisions through the accurate presentation at the cell surface of a complex array of biochemical and biophysical signals that are mediated by the structure and composition of the extracellular matrix (ECM). On the one hand, the cells actively remodel the ECM, which on the other hand affects cell functions. This cell–ECM dynamic reciprocity is central in...

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PMID: 37434756
DOI: 10.3389/fbioe.2023.1197075

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