Article
Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study.
Frontiers in endocrinology - 1 Jan 2023
Otomo Nao, Khanshour Anas M, Koido Masaru, Takeda Kazuki, Momozawa Yukihide, Kubo Michiaki, Kamatani Yoichiro, Herring John A, Ogura Yoji, Takahashi Yohei, Minami Shohei, Uno Koki, Kawakami Noriaki, Ito Manabu, Sato Tatsuya, Watanabe Kei, Kaito Takashi, Yanagida Haruhisa, Taneichi Hiroshi, Harimaya Katsumi, Taniguchi Yuki, Shigematsu Hideki, Iida Takahiro, Demura Satoru, Sugawara Ryo, Fujita Nobuyuki, Yagi Mitsuru, Okada Eijiro, Hosogane Naobumi, Kono Katsuki, Nakamura Masaya, Chiba Kazuhiro, Kotani Toshiaki, Sakuma Tsuyoshi, Akazawa Tsutomu, Suzuki Teppei, Nishida Kotaro, Kakutani Kenichiro, Tsuji Taichi, Sudo Hideki, Iwata Akira, Inami Satoshi, Wise Carol A, Kochi Yuta, Matsumoto Morio, Ikegawa Shiro, Watanabe Kota, Terao Chikashi
Abstract excerpt
Introduction: Adolescent idiopathic scoliosis (AIS) is a disorder with a three-dimensional spinal deformity and is a common disease affecting 1-5% of adolescents. AIS is also known as a complex disease involved in environmental and genetic factors. A relation between AIS and body mass index (BMI) has been epidemiologically and genetically suggested. However, the causal relationship between AIS and BMI remains to...
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