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Article

Impact of lumacaftor/ivacaftor and tezacaftor/ivacaftor on treatment response in pulmonary exacerbations of F508del/F508del cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Sept 2023

McElvaney Oliver J, Heltshe Sonya L, Odem-Davis Katherine, West Natalie E, Sanders Don B, Fogarty Barbra, VanDevanter Donald R, Flume Patrick A, Goss Christopher H

Abstract excerpt

BACKGROUND: Pulmonary exacerbations (PEx) remain a major cause of morbidity and mortality in people with cystic fibrosis (PWCF). Although the combination cystic fibrosis transmembrane conductance regulator (CFTR) modulators lumacaftor/ivacaftor and tezacaftor/ivacaftor have been shown to reduce PEx frequency, their influence on clinical and biochemical responses to acute PEx treatment is unknown. METHODS: We...

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Identifiers

PMID: 37407341
DOI: 10.1016/j.jcf.2023.06.012
PMCID: PMC10761587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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