Article
Impact of elexacaftor-tezacaftor-ivacaftor on bacterial colonization and inflammatory responses in cystic fibrosis.
Pediatric pulmonology - 1 Mar 2023
Sheikh Shahid, Britt Rodney D, Ryan-Wenger Nancy A, Khan Aiman Q, Lewis Brandon W, Gushue Courtney, Ozuna Hazel, Jaganathan Devi, McCoy Karen, Kopp Benjamin T
Abstract excerpt
BACKGROUND: Cystic fibrosis (CF) is a multisystem disease with progressive deterioration. Recently, CF transmembrane conductance regulator (CFTR) modulator therapies were introduced that repair underlying protein defects. Objective of this study was to determine the impact of elexacaftor-tezacaftor-ivacaftor (ETI) on clinical parameters and inflammatory responses in people with CF (pwCF). METHODS: Lung function...
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