Article
The role of B cells in immune cell activation in polycystic ovary syndrome.
eLife - 4 Jul 2023
Ascani Angelo, Torstensson Sara, Risal Sanjiv, Lu Haojiang, Eriksson Gustaw, Li Congru, Teschl Sabrina, Menezes Joana, Sandor Katalin, Ohlsson Claes, Svensson Camilla I, Karlsson Mikael C I, Stradner Martin Helmut, Obermayer-Pietsch Barbara, Stener-Victorin Elisabet
Abstract excerpt
Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here, we demonstrate that B cells are not central mediators of PCOS pathology and that their frequencies are altered as a direct effect of androgen receptor activation. Hyperandrogenic women with PCOS have increased frequencies of age-associated double-negative B memory cells and increased levels of...
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