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Article

Effects of spaced k-mers on alignment-free genotyping.

Bioinformatics (Oxford, England) - 30 Jun 2023

Häntze Hartmut, Horton Paul

Abstract excerpt

MOTIVATION: Alignment-free, k-mer based genotyping methods are a fast alternative to alignment-based methods and are particularly well suited for genotyping larger cohorts. The sensitivity of algorithms, that work with k-mers, can be increased by using spaced seeds, however, the application of spaced seeds in k-mer based genotyping methods has not been researched yet. RESULTS: We add a spaced seeds functionality...

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PMID: 37387138
DOI: 10.1093/bioinformatics/btad202
PMCID: PMC10311327

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