Article
Mechanisms of fever-induced QT prolongation and torsades de pointes in patients with KCNH2 mutation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 2 Jun 2023
Usuda Keisuke, Hayashi Kenshi, Nakajima Tadashi, Kurata Yasutaka, Cui Shihe, Kusayama Takashi, Tsuda Toyonobu, Tada Hayato, Kato Takeshi, Sakata Kenji, Usui Soichiro, Fujino Noboru, Tanaka Yoshihiro, Kaneko Yoshiaki, Kurabayashi Masahiko, Tange Shoichi, Saito Takekatsu, Ohta Kunio, Yamagishi Masakazu, Takamura Masayuki
Abstract excerpt
AIMS: Patients with particular mutations of type-2 long QT syndrome (LQT2) are at an increased risk for malignant arrhythmia during fever. This study aimed to determine the mechanism by which KCNH2 mutations cause fever-induced QT prolongation and torsades de pointes (TdP). METHODS AND RESULTS: We evaluated three KCNH2 mutations, G584S, D609G, and T613M, in the Kv11.1 S5-pore region, identified in patients with...
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