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Article

High-grade Serous Carcinoma can Show Squamoid Morphology Mimicking True Squamous Differentiation.

The American journal of surgical pathology - 1 Sept 2023

Tomonobe Hiroshi, Ohishi Yoshihiro, Hachisuga Kazuhisa, Yahata Hideaki, Kato Kiyoko, Oda Yoshinao

Abstract excerpt

Tubo-ovarian high-grade serous carcinoma (HG-SC) and ovarian endometrioid carcinoma (EC) can show overlapping morphologic features, such as glandular and solid patterns. The differential diagnosis of these subtypes is thus sometimes difficult. The existence of "squamous differentiation" tends to lead to a diagnosis of EC rather than HG-SC. We noticed that HG-SC can contain a "squamoid component," but its nature...

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Identifiers

PMID: 37382102
DOI: 10.1097/PAS.0000000000002089

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