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Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma

12 Jun 2023

Abstract excerpt

Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenvironment (TME). Methods: Correlation between PD-L1 expression and iron content within the TME was established on FFPE LUAD tissue samples. The effects of an iron rich...

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PMID: 37377735
DOI: 10.3389/fcell.2023.1208485

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