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Article

Dysregulated ferroptosis-related genes indicate potential clinical benefits for anti-PD-1/PD-L1 immunotherapy in lung adenocarcinoma.

Journal of clinical laboratory analysis - 1 Dec 2021

Zhou Min, Zhang Xiuxiu, Li Tianyang, Chen Yan

Abstract excerpt

BACKGROUND: Ferroptosis is an iron-dependent programmed cell death mechanism that influences the development of malignancy. Lung adenocarcinoma (LUAD) is the most common type of lung cancer with no known cure. Anti-PD-1/PD-L immunotherapy is effective for patients with partial LUAD. Therefore, there is an immediate requirement of novel markers to predict the individualised benefits of immunotherapy. METHODS: We...

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PMID: 34752672
DOI: 10.1002/jcla.24086
PMCID: PMC8649384

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