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An Integrated Computational Analysis of High-Risk SNPs in Angiopoietin-like Proteins (ANGPTL3 and ANGPTL8) Reveals Perturbed Protein Dynamics Associated with Cancer.

Molecules (Basel, Switzerland) - 8 Jun 2023

Iqbal Sajid, Begum Farida, Nyamai Dorothy Wavinya, Jalal Nasir, Shaw Peter

Abstract excerpt

Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1-8) which play a pivotal role in the regulation of various pathophysiological processes. The current study sought to identify high-risk, "non-synonymous, single-nucleotide polymorphisms" (nsSNPs) in both ANGPTL3 and ANGPTL8 to evaluate the role that these nsSNPs play in various types of cancer. We retrieved a total of 301 nsSNPs from...

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PMID: 37375208
DOI: 10.3390/molecules28124648
PMCID: PMC10303706

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