A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations.

Abstract excerpt

We developed a rapid and accurate biosensor to detect SARS-CoV-2 and distinguish its mutations. Benefitting from a DNA framework-modified ordered interface and a dual signal amplification strategy, our biosensor could detect SARS-CoV-2 with a detection limit down to 10 fM. It performed well on pseudo virus and SARS-CoV-2 RNA standard materials, revealing the potential application in disease diagnosis and spread,...

Topics

Join the communities discussing this publication.

• Biosensing Techniques
• COVID-19
• DNA
• Mutation
• RNA, Viral