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Article

First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene.

Annals of clinical biochemistry - 1 Sept 2023

Sienes Bailo Paula, Goñi Ros Nuria, Menéndez Jándula Bárbara, Álvarez Alegret Ramiro, González Gómez Eduardo, González Tarancón Ricardo, Izquierdo Álvarez Silvia

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by...

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PMID: 37365821
DOI: 10.1177/00045632231186076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene.PMID 37365821Read ↗

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