Article
Detection of a knockdown mutation in the voltage-sensitive sodium channel associated with permethrin tolerance in Sarcoptes scabiei var. hominis mites.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Nov 2023
Riebenbauer K, Purkhauser K, Walochnik J, Urban N, Weber P B, Stamm T, Handisurya A
Abstract excerpt
BACKGROUND: Increasing evidence has sparked a debate on the loss of sensitivity of scabies mites to conventional permethrin therapy. Mutations in the voltage-sensitive sodium channels (VSSC) were associated with knockdown resistance (kdr) in many arthropods, but have never been identified in Sarcoptes scabiei variatio (var.) hominis mites. OBJECTIVES: To identify factors contributing to therapy failure. METHODS:...
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