Article
A Noncoding A-to-U Kozak Site Change Related to the High Transmissibility of Alpha, Delta, and Omicron VOCs.
Molecular biology and evolution - 1 Jun 2023
Yang Jianing, Cui Yingmin, Yu Dalang, Zhang Guoqing, Cao Ruifang, Gu Zhili, Dai Guangyi, Wu Xiaoxian, Ling Yunchao, Yi Chunyan, Sun Xiaoyu, Sun Bing, Lin Xin, Zhang Yu, Zhao Guo-Ping, Li Yixue, Pan Yi-Hsuan, Li Haipeng
Abstract excerpt
Three prevalent SARS-CoV-2 variants of concern (VOCs) emerged and caused epidemic waves. It is essential to uncover advantageous mutations that cause the high transmissibility of VOCs. However, viral mutations are tightly linked, so traditional population genetic methods, including machine learning-based methods, cannot reliably detect mutations conferring a fitness advantage. In this study, we developed an...
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