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Article

VOC-alarm: mutation-based prediction of SARS-CoV-2 variants of concern.

Bioinformatics (Oxford, England) - 11 Jul 2022

Zhao Hongyu, Han Kun, Gao Chao, Madhira Vithal, Topaloglu Umit, Lu Yong, Jin Guangxu

Abstract excerpt

SUMMARY: Mutation is the key for a variant of concern (VOC) to overcome selective pressures, but this process is still unclear. Understanding the association of the mutational process with VOCs is an unmet need. Motivation: Here, we developed VOC-alarm, a method to predict VOCs and their caused COVID surges, using mutations of about 5.7 million SARS-CoV-2 complete sequences. We found that VOCs rely on...

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PMID: 35640977
DOI: 10.1093/bioinformatics/btac370
PMCID: PMC9272809

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