Discussion of off-target and tentative genomic findings may sometimes be necessary to allow evaluation of their clinical significance.

Abstract excerpt

We discuss a case where clinical genomic investigation of muscle weakness unexpectedly found a genetic variant that might (or might not) predispose to kidney cancer. We argue that despite its off-target and uncertain nature, this variant should be discussed with the man who had the test, not because it is medical information, but because this discussion would allow the further clinical evaluation that might lead...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clinical Relevance
• Share to Genetic Predisposition to Disease