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Article

Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance.

Journal of physiology and biochemistry - 1 Aug 2023

Lendoiro-Cino Natalia, Rodríguez-Coello Arianna, Saborido Anna, F-Burguera Elena, Fernández-Rodríguez Jennifer A, Meijide-Faílde Rosa, Blanco Francisco J, Vaamonde-García Carlos

Abstract excerpt

Type 2 diabetes (DB) is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Synovial macrophages from OA patients with DB present a marked pro-inflammatory phenotype. Since hydrogen sulphide (H2S) has been previously described to be involved in macrophage polarization, in this study we examined H2S biosynthesis in synovial...

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Identifiers

PMID: 37335394
DOI: 10.1007/s13105-023-00968-y
PMCID: PMC10338594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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