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Alzheimer's Disease and Neurosyphilis: Meaningful Commonalities and Differences of Clinical Phenotype and Pathophysiological Biomarkers.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Milano Chiara, Hoxhaj Domeniko, Del Chicca Marta, Pascazio Alessia, Paoli Davide, Tommasini Luca, Vergallo Andrea, Pizzanelli Chiara, Tognoni Gloria, Nuti Angelo, Ceravolo Roberto, Siciliano Gabriele, Hampel Harald, Baldacci Filippo

Abstract excerpt

BACKGROUND: Neurosyphilis-associated cognitive and behavioral impairment- historically coined as "general paralysis of the insane"- share clinical and neuroradiological features with the neurodegenerative disease spectrum, in particular Alzheimer's disease (AD). Anatomopathological similarities have been extensively documented, i.e., neuronal loss, fibrillary alterations, and local amyloid-β deposition....

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PMID: 37334599
DOI: 10.3233/JAD-230170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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