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Article

Real-world evaluation of Armstrong's criteria in corticobasal degeneration: Phenotypic overlap and diagnostic challenges.

Parkinsonism & related disorders - 1 Apr 2026

Morihara Ryuta, Nomura Emi, Osakada Yosuke, Yunoki Taijun, Takemoto Mami, Yamashita Toru, Ishiura Hiroyuki

Abstract excerpt

BACKGROUND: Corticobasal degeneration (CBD) is a four-repeat tauopathy with heterogeneous clinical manifestations. Armstrong's criteria involve a two-step diagnostic approach: first, classifying patients into five clinical phenotypes-probable/possible corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), non-fluent/agrammatic variant primary progressive aphasia (naPPA), and progressive...

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PMID: 41671870
DOI: 10.1016/j.parkreldis.2026.108229

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CBS

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