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Mitochondrial uncouplers impair human sperm motility without altering ATP content

8 Jun 2023

Abstract excerpt

In human spermatozoa, the electrochemical potentials across the mitochondrial and plasma membranes are related to sperm functionality and fertility, but the exact role of each potential has yet to be clarified. Impairing sperm mitochondrial function has been considered as an approach to creating male or unisex contraceptives, but it has yet to be shown whether this approach would ultimately block the ability of...

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PMID: 37294625
DOI: 10.1093/biolre/ioad064

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