Article
Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian Randomization study.
Translational psychiatry - 8 Jun 2023
Zhao Guorui, Lu Zhe, Sun Yaoyao, Kang Zhewei, Feng Xiaoyang, Liao Yundan, Sun Junyuan, Zhang Yuyanan, Huang Yu, Yue Weihua
Abstract excerpt
A growing body of research suggests that social or physical activity can affect the risk of Major depressive disorder (MDD). However, the bidirectional relationship between them remains to be clarified further, especially between inactivity and MDD. Here, we performed a two-sample Mendelian Randomization analysis using genetic variants associated with social/physical activities and MDD, and assessed the mediating...
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