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Article

Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms.

Circulation. Genomic and precision medicine - 1 Aug 2023

Wang Xin, Khurshid Shaan, Choi Seung Hoan, Friedman Samuel, Weng Lu-Chen, Reeder Christopher, Pirruccello James P, Singh Pulkit, Lau Emily S, Venn Rachael, Diamant Nate, Di Achille Paolo, Philippakis Anthony, Anderson Christopher D, Ho Jennifer E, Ellinor Patrick T, Batra Puneet, Lubitz Steven A

Abstract excerpt

BACKGROUND: Artificial intelligence (AI) models applied to 12-lead ECG waveforms can predict atrial fibrillation (AF), a heritable and morbid arrhythmia. However, the factors forming the basis of risk predictions from AI models are usually not well understood. We hypothesized that there might be a genetic basis for an AI algorithm for predicting the 5-year risk of new-onset AF using 12-lead ECGs (ECG-AI)-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37278238
DOI: 10.1161/CIRCGEN.122.003808
PMCID: PMC10524395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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