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Beyond the state of the art of reverse vaccinology: predicting vaccine efficacy with the universal immune system simulator for influenza

4 Jun 2023

Abstract excerpt

When it was first introduced in 2000, reverse vaccinology was defined as an in silico approach that begins with the pathogen's genomic sequence. It concludes with a list of potential proteins with a possible, but not necessarily, list of peptide candidates that need to be experimentally confirmed for vaccine production. During the subsequent years, reverse vaccinology has dramatically changed: now it consists of...

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PMID: 37271819
DOI: 10.1186/s12859-023-05374-1

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