Article
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors.
International journal for parasitology. Drugs and drug resistance - 1 Aug 2023
Choubey Deepak, Deshmukh Bhagyashree, Rao Anjani Gopal, Kanyal Abhishek, Hati Amiya Kumar, Roy Somenath, Karmodiya Krishanpal
Abstract excerpt
The emergence of drug resistance to frontline treatments such as Artemisinin-based combination therapy (ACT) is a major obstacle to the control and eradication of malaria. This problem is compounded by the inherent genetic variability of the parasites, as many established markers of resistance do not accurately predict the drug-resistant status. There have been reports of declining effectiveness of ACT in the...
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