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Optimization and Deoptimization of Codons in SARS-CoV-2 and Related Implications for Vaccine Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2023

Wu Xinkai, Shan Ke-Jia, Zan Fuwen, Tang Xiaolu, Qian Zhaohui, Lu Jian

Abstract excerpt

The spread of coronavirus disease 2019 (COVID-19), caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has progressed into a global pandemic. To date, thousands of genetic variants have been identified among SARS-CoV-2 isolates collected from patients. Sequence analysis reveals that the codon adaptation index (CAI) values of viral sequences have decreased over time but with occasional fluctuations....

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Identifiers

PMID: 37267926
DOI: 10.1002/advs.202205445
PMCID: PMC10427376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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