Article
Selpercatinib monotherapy in a Chinese patient with RET fusion/ EGFR co-mutated nonsmall cell lung cancer from the Phase II LIBRETTO-321 study: a case report.
Anti-cancer drugs - 1 Oct 2023
Wu Lin, Cheng Ying, Huang Dingzhi, Sun Yuping, Zhou Chengzhi, Zhou Jianying, Guo Ye, Shao Jingxin, Zhang Wanli, Lu Shun
Abstract excerpt
Rearranged during transfection ( RET ) fusions and epidermal growth factor receptor ( EGFR ) mutations are potent oncogenic drivers in patients with nonsmall cell lung cancer (NSCLC), but rarely co-exist. Concurrent RET/EGFR mutations have been reported in patients with NSCLC who develop resistance to EGFR tyrosine kinase inhibitors but are even less frequent in treatment-naïve patients. Consequently, there is no...
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