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Article

Therapeutic strategies in RET gene rearranged non-small cell lung cancer

26 Mar 2021

Abstract excerpt

The recent approvals by the Food and Drug Administration several tumor-agnostic drugs have resulted in a paradigm shift in cancer treatment from an organ/histology-specific strategy to biomarker-guided approaches. RET gene fusions are oncogenic drivers in multiple tumor types and are known to occur in 1-2% of non-squamous NSCLC patients. RET gene fusions give rise to chimeric, cytosolic proteins with...

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PMID: 33771190
DOI: 10.1186/s13045-021-01063-9

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