Article
Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses.
The Journal of infection - 1 Jul 2023
Qian Zhongyao, Li Tengyuan, Xia Yueping, Cong Chao, Chen Shuangfeng, Zhang Yike, Gong Shiling, Wang Wenjing, Liu Huichan, Chen Dongxue, Zhao Wanqiu, Zhong Guo, Deng Yinlong, Yu Wenhai, Wei Daqiao, Yu Xiongwu, Huang Fen
Abstract excerpt
BACKGROUND: Hepatitis E virus (HEV) infection in pregnant women causes adverse pregnancy outcomes, including maternal death, premature delivery, stillbirth, and fetal infection. However, the pathogenesis of maternal and fetal HEV infection is unclear. METHODS: Placenta and placental appendixes were collected from HEV-4 infected pregnant women to explore the vertical transmission of HEV from mothers to fetuses....
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